The effects of the saponinic summ extracted from roots of Aralia mandshurica have been studied in experimentally animals exposed to stress.
Material and methods: The experiment was carried out on 4 groups of animals divided into 24 lots of 12 white rats each with experimentally induced chronic inflammation or/and exposed to stress induced by exposure to continuous dark or light. The drugs (Levamisole (LVM) (10mg/kg bw/day), Indometacin (IND) (1.42 mg/kg bw/day), Extract of the roots of Aralia mandshurica (SAR) (26.25 mg/kg bw/day) and saline solution (0.5 mL/100 g bw/day) were administered orally for 14 days, in unique daily dose. Blood samples were taken from rats' retroorbital plexus before the beginning of the treatment protocol (M0) and at the finish of the treatment (M1) in order to assay differential cell count, peripheral neutrophils activity (NBT test) and serum complement activity.
Results: The SAR extracts exert influence on immunity defence cellular's components without influence on humoral efects, no matter of experimentally conditions. They determined decreasing of the percentage of the neutrophils in peripheral blood (at the lower levels than Indometacin (IND).
Conclusion: The experimental results demonstrated immunomodulatory effect of this saponine extract.