Eosinophilic esophagitis is a clinicopathological disease characterized by GERD-like symptoms, food impaction and dysphagia that occur with the histological finding of dense esophageal eosinophilia. Endoscopic features include linear furrows, white exudate and longitudinal shearing. Current concepts regarding the pathophysiology relate to a food allergen-induced overexpression of eosinophil-related cytokines including Il-5, IL-13 and eotaxin-3. Effective treatments include topical and systemic corticosteroids and dietary restrictions.
Copyright 2010 S. Karger AG, Basel.