Extensively drug-resistant Mycobacterium tuberculosis from aspirates, Rural South Africa

Scott K Heysell; Anthony P Moll; Neel R Gandhi; Francois J Eksteen; Palav Babaria; Yacoob Coovadia; Lynn Roux; Umesh Lalloo; Gerald Friedland; N Sarita Shah

doi:10.3201/eid1603.091486

Extensively drug-resistant Mycobacterium tuberculosis from aspirates, Rural South Africa

Emerg Infect Dis. 2010 Mar;16(3):557-60. doi: 10.3201/eid1603.091486.

Authors

Scott K Heysell¹, Anthony P Moll, Neel R Gandhi, Francois J Eksteen, Palav Babaria, Yacoob Coovadia, Lynn Roux, Umesh Lalloo, Gerald Friedland, N Sarita Shah

Affiliation

¹ Tugela Ferry Care and Research Collaboration, Tugela Ferry, South Africa. scott.heysell@gmail.com

Abstract

The yield from aspirating lymph nodes and pleural fluid for diagnosing extensively drug-resistant (XDR) tuberculosis is unknown. Mycobacterium tuberculosis was cultured from lymph node or pleural fluid aspirates of 21 patients; 7 (33%) cultures grew XDR M. tuberculosis. Additive diagnostic yield for XDR M. tuberculosis was found in parallel culture of sputum and fluid aspirate.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

AIDS-Related Opportunistic Infections / diagnosis
AIDS-Related Opportunistic Infections / microbiology
Adult
Antitubercular Agents / pharmacology
Biopsy, Fine-Needle / methods*
Culture Media
Drug Resistance, Multiple, Bacterial
Extensively Drug-Resistant Tuberculosis / diagnosis*
Extensively Drug-Resistant Tuberculosis / microbiology
Female
HIV Infections / complications
Humans
Lymph Nodes / microbiology*
Male
Microbial Sensitivity Tests
Mycobacterium tuberculosis / drug effects
Mycobacterium tuberculosis / isolation & purification*
Pleural Effusion / microbiology*
Rural Population
South Africa

Substances

Antitubercular Agents
Culture Media