The classical model of sugar absorption indicates that Na+ -glucose cotransporter, SGLT1 transports glucose from intestinal lumen to cytosol and GLUT2 transports glucose from cytosol to the blood. Recent evidence indicates that GLUT 2 is rapidly inserted into the apical membrane after a meal. Intestinal glucose absorption by the apical GLUT2 pathway can be 3 to 5-times greater then by SGLT1 et the high concentration of sugar. Apical GLUT2 insertion is regulated by pathway of calcium absorption through L-type channel Ca(v)1.3, activation of sweet taste receptors (T1R2/F1R3) and endocrine and paracrine hormones (especially insulin and GLP-2).