[Thermal stability evaluation of some W/O/W double emulsions containing 1% piroxicam by rheological measurements]

Rev Med Chir Soc Med Nat Iasi. 2009 Jul-Sep;113(3):921-6.
[Article in Romanian]

Abstract

The aim of this work was to evaluate thermal stability of some W/O/W concentrated double emulsions (with 80% dispersed phase) containing 1% piroxicam following their theological behaviour at various temperatures. W/O/W double emulsions containing 1% piroxicam were prepared using the two-step procedure.

Results: The variable parameter of formulations was the hydrophilic macromolecule compound dispersed in the internal and external aqueous phases (hydroxyethylcellulose and Carbopol 940). Rheological behaviour and viscosity of the obtained W/O/W double emulsions was measured at 15 degrees C, 20 degrees C, 25 degrees C, 30 degrees C and 35 degrees C respectively, after preparation. The obtained results demonstrated that the studied W1/O/W2 double emulsions containing 1% piroxicam were stable under applied thermal stress, although they exhibited some differences in rheological properties caused by formulation variable.

Publication types

  • English Abstract

MeSH terms

  • Anti-Inflammatory Agents, Non-Steroidal / chemistry*
  • Chemistry, Pharmaceutical
  • Drug Stability
  • Emulsions / chemistry
  • Humans
  • Piroxicam / chemistry*
  • Rheology / methods*
  • Temperature*
  • Viscosity
  • Water / chemistry*

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Emulsions
  • Water
  • Piroxicam