Abstract
A new phenolic amide, tribulusimide D (4-hydroxy-N-[3-(4-hydroxy-3-methoxyphenyl)-1-oxo-2-propen-1-yl]-3-methoxybenzamide) (1), together with a known phenolic amide, terrestriamide ((E)-3-(4-hydroxy-3-methoxyphenyl)-N-[2-(4-hydroxyphenyl)-2-oxoethyl]-prop-2-enamide) (2) and a flavonol glycoside, quercetin-3-O-beta-D-glucopyranosyl-(1-->6)-beta-D-glucopyranoside (3) were isolated from the H2O extract of Tribuli Fructus. Compounds 1 and 3 showed significant hepatoprotective activities, with EC50 values of 13.46 +/- 0.2 and 7.06 +/- 0.7 microM, respectively, against tacrine-induced cytotoxicity in HepG2 cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Carbohydrate Sequence
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Cell Line
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Chemical and Drug Induced Liver Injury / pathology
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Chemical and Drug Induced Liver Injury / prevention & control*
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Fruit / chemistry
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Guaiacol / analogs & derivatives*
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Guaiacol / chemistry
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Guaiacol / pharmacology
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Imides / chemistry*
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Imides / pharmacology*
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Molecular Sequence Data
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Nootropic Agents / toxicity*
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Plant Extracts / chemistry
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Protective Agents / chemistry*
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Protective Agents / pharmacology*
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Spectrometry, Mass, Electrospray Ionization
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Tacrine / antagonists & inhibitors*
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Tacrine / toxicity*
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Tribulus / chemistry*
Substances
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4-hydroxy-N-(3-(4-hydroxy-3-methoxyphenyl)-1-oxo-2-propen-1-yl)-3-methoxybenzamide
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Imides
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Nootropic Agents
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Plant Extracts
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Protective Agents
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Tacrine
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Guaiacol