Abstract
Honokiol, a major phenolic constituent of Magnolia sp., has various pharmacological activities. To improve the solubility and antibacterial activity of honokiol against E. coli and P. aeruginosa, new honokiol-derivatives (honokiol-acetate, honokiol-succinic acid, honokiol-glycerol, honokiol-glycine, honokiol-glucose and honokiol-mannose) were synthesized and their solubility and antimicrobial activities were investigated. Among the tested compounds, honokiol-glycine showed improved water solubility and antibacterial activities against E. coli and P. aeruginosa when compared to honokiol.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Infective Agents / chemical synthesis*
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Anti-Infective Agents / chemistry
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Anti-Infective Agents / pharmacology*
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Antifungal Agents / chemical synthesis
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Antifungal Agents / pharmacology
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Bacteria / drug effects*
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Biphenyl Compounds / chemical synthesis*
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Biphenyl Compounds / chemistry
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Biphenyl Compounds / pharmacology*
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Escherichia coli / drug effects
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Fungi / drug effects
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Lignans / chemical synthesis*
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Lignans / chemistry
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Lignans / pharmacology*
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Microbial Sensitivity Tests
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Pseudomonas aeruginosa / drug effects
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Solubility
Substances
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Anti-Infective Agents
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Antifungal Agents
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Biphenyl Compounds
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Lignans
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honokiol