Purpose: A population-based study of cervical intraepithelial neoplasia grade 3 (CIN3) has hitherto not been performed in Israel. The aim of the present study was to assess selected demographic characteristics of Israeli Jewish CIN3 patients in an attempt to identify the risk factors in this population.
Methods: All CIN3 patients diagnosed during 2002-2004 according to the Israel National Cancer Registry were included. Demographic and population data were obtained from the Central Population Registry and from the Israel Central Bureau of Statistics annual abstract reports. The age-standardized incidence rate (ASR) and rate ratios (RR) for each demographic category were calculated.
Results: The study comprised 1,108 CIN3 patients (mean age 38.4 years) yielding an ASR of 13.9/100.000. A significantly greater number of CIN3 in the 30-39-year (RR = 2.16) and 40-49-year (RR = 1.74) age groups were observed. The overall rate of single and married women was similar, that in widowed women significantly lower and divorced women significantly higher (RR = 2.37) than in the general population. The mean number of children was 1.7. The rate of patients with 5 + children was significantly higher only in the 30-39-year age group. RR varied with age within each demographic category. The rate of Israeli born was higher and that of other ethnic origins was similar to the population rates. No association between CIN3 and socioeconomic status was found.
Conclusion: Greater CIN3 rates were observed in women of 30-49 years, divorced women and Israeli-born women. Great differences in RR between age groups within the demographic categories were observed.