Inflammatory twins from PI3K gang brought to justice?

Philip E Thompson; Ian G Jennings; Jo-Anne Pinson

doi:10.1016/j.chembiol.2010.02.001

Inflammatory twins from PI3K gang brought to justice?

Chem Biol. 2010 Feb 26;17(2):101-2. doi: 10.1016/j.chembiol.2010.02.001.

Authors

Philip E Thompson¹, Ian G Jennings, Jo-Anne Pinson

Affiliation

¹ Medicinal Chemistry and Drug Action, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville 3052, Australia. philip.thompson@pharm.monash.edu.ac

PMID: 20189098
DOI: 10.1016/j.chembiol.2010.02.001

Abstract

PI3 kinase inhibitors are hot property. In this issue of Chemistry & Biology, Williams et al. add a dual PI3Kdelta/gamma inhibitor to the collection and show that its anti-inflammatory profile in vitro is quite different from pan-PI3K inhibitors, but bears an uncanny resemblance to that of the glucocorticoid drugs.