Abstract
The cellular surveillance systems guarantee proper removal of altered components from inside cells. Alterations of these systems in neurons have been proposed to be involved in the pathogenesis of different neurodegenerative disorders. In this review, we comment on the advances in our current understanding of how changes in the intracellular proteolytic systems, the main components of the cellular quality control system, contribute to neurodegeneration, with special emphasis on Parkinson's disease.
Publication types
-
Research Support, N.I.H., Extramural
-
Research Support, Non-U.S. Gov't
-
Review
MeSH terms
-
Animals
-
Autophagy / physiology
-
Humans
-
Models, Molecular
-
Neurons / metabolism
-
Neurons / pathology
-
Parkinson Disease* / metabolism
-
Parkinson Disease* / pathology
-
Proteasome Endopeptidase Complex / metabolism
-
Protein Conformation
-
Protein Folding*
-
Proteins / metabolism*
-
Ubiquitin / metabolism
-
alpha-Synuclein / metabolism
Substances
-
Proteins
-
Ubiquitin
-
alpha-Synuclein
-
Proteasome Endopeptidase Complex