Antimicrobial activity of long-chain (E)-3-alken-2-ones

William F Wood; Aya Kubo; Tony B Shaffer

doi:10.1016/j.bmcl.2010.02.016

Antimicrobial activity of long-chain (E)-3-alken-2-ones

Bioorg Med Chem Lett. 2010 Mar 15;20(6):1819-20. doi: 10.1016/j.bmcl.2010.02.016. Epub 2010 Feb 8.

Authors

William F Wood¹, Aya Kubo, Tony B Shaffer

Affiliation

¹ Department of Chemistry, Humboldt State University, Arcata, CA 95521, USA. wfw2@humboldt.edu

PMID: 20185306
DOI: 10.1016/j.bmcl.2010.02.016

Abstract

(E)-3-tridecen-2-one, a compound identified from the interdigital glands of black-tailed deer (Odocoileus hemionus columbianus), has been shown to inhibit the growth of bacteria and fungi. Homologues of (E)-3-tridecen-2-one were prepared and screened for antimicrobial activity. For the fungus, Trichophyton mentagrophytes, the minimum inhibitory concentration (MIC) of (E)-3-Tetradecen-2-one was 12.5 microg/mL, and for the bacteria, Propionibacterium acnes, the MIC of (E)-3-heptadecen-2-one was 3.13 microg/mL.

MeSH terms

Alkenes / pharmacology*
Anti-Infective Agents / pharmacology*
Microbial Sensitivity Tests
Propionibacterium acnes / drug effects
Trichophyton / drug effects

Substances

3-tridecen-2-one
Alkenes
Anti-Infective Agents