Cellular sources of tissue factor in endotoxemia and sepsis

Thromb Res. 2010 Apr:125 Suppl 1:S70-3. doi: 10.1016/j.thromres.2010.01.042. Epub 2010 Feb 24.

Abstract

Sepsis is a systemic host response to infection by pathogenic microorganisms. Activation of the coagulation cascade during endotoxemia and sepsis leads to disseminated intravascular coagulation. This review focuses on tissue factor expression by hematopoietic and non-hematopoietic cells and its contribution to the activation of coagulation during endotoxemia and sepsis.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antithrombins / chemistry
  • Blood Coagulation
  • Endothelial Cells / chemistry
  • Endotoxemia / metabolism*
  • Hematopoiesis
  • Humans
  • Lipopolysaccharides / chemistry
  • Models, Biological
  • Sepsis / metabolism*
  • Thrombin / chemistry
  • Thromboplastin / metabolism*

Substances

  • Antithrombins
  • Lipopolysaccharides
  • Thromboplastin
  • Thrombin