Abstract
Sepsis is a systemic host response to infection by pathogenic microorganisms. Activation of the coagulation cascade during endotoxemia and sepsis leads to disseminated intravascular coagulation. This review focuses on tissue factor expression by hematopoietic and non-hematopoietic cells and its contribution to the activation of coagulation during endotoxemia and sepsis.
Copyright (c) 2010 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Antithrombins / chemistry
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Blood Coagulation
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Endothelial Cells / chemistry
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Endotoxemia / metabolism*
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Hematopoiesis
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Humans
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Lipopolysaccharides / chemistry
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Models, Biological
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Sepsis / metabolism*
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Thrombin / chemistry
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Thromboplastin / metabolism*
Substances
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Antithrombins
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Lipopolysaccharides
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Thromboplastin
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Thrombin