Synthesis of novel 5'-uridine-head amphiphiles as model for DNA molecular recognition

Nucleosides Nucleotides Nucleic Acids. 2009 Oct;28(10):911-23. doi: 10.1080/15257770903306625.

Abstract

Here we describe uridine functionalization in the 5' position, which provides new classes of cationic and nonionic amphiphiles specifically designed as DNA transfection agents. The synthetic procedures developed to obtain the cationic uridine-head surfactants prevented intramolecular cyclization that occurs when uridine is functionalized in this position without using protecting groups in the uracil.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cyclization
  • DNA / chemistry*
  • DNA / metabolism
  • Models, Molecular
  • Surface-Active Agents / chemical synthesis*
  • Surface-Active Agents / chemistry*
  • Transfection
  • Uridine / analogs & derivatives
  • Uridine / chemical synthesis*
  • Uridine / chemistry*

Substances

  • Surface-Active Agents
  • DNA
  • Uridine