Four new long-chain aliphatics from the feces of Trogopterus xanthipes

J Asian Nat Prod Res. 2009 Dec;11(12):1032-9. doi: 10.1080/10286020903352518.

Abstract

Chemical investigation of Trogopterus feces has led to the isolation of four new long-chain aliphatics, including two new fatty alcohols, 8,15-nonacosanediol (1) and 6,13-nonacosanediol (2), one new fatty acid ester, dihexyl 7,7'-oxydiheptanoate (3), and one new ceramide, (2R)-2-hydroxy-N-[(2S,3S,4R,11E)-1,3,4-trihydroxydocos-11-en-2-yl]heneicosanamide (4). Their structures were elucidated by means of chemical and extensive spectroscopic analysis. Compound 3 exhibited moderate activity of antithrombin in vitro.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anticoagulants / chemistry
  • Anticoagulants / isolation & purification*
  • Anticoagulants / pharmacology
  • Ceramides / chemistry
  • Fatty Alcohols / chemistry
  • Fatty Alcohols / isolation & purification*
  • Fatty Alcohols / pharmacology
  • Feces / chemistry
  • Fibrinolytic Agents / chemistry
  • Fibrinolytic Agents / isolation & purification*
  • Fibrinolytic Agents / pharmacology
  • Molecular Structure
  • Sciuridae*
  • Stereoisomerism

Substances

  • Anticoagulants
  • Ceramides
  • Fatty Alcohols
  • Fibrinolytic Agents