Abstract
The design, synthesis and evaluation of methyl 1,2,8,8a-tetrahydrocyclopropa[c]oxazolo[2,3-e]indol-4-one-6-carboxylate (COI) derivatives are detailed representing analogs of duocarmycin SA containing an oxazole replacement for the fused pyrrole found in the alkylation subunit.
Copyright 2010 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkylating Agents / chemical synthesis*
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Alkylating Agents / chemistry
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Alkylating Agents / pharmacology*
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Alkylation
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Duocarmycins
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Indoles / chemical synthesis
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Indoles / chemistry*
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Indoles / pharmacology
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Oxazoles / chemistry*
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Pyrroles / chemical synthesis
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Pyrroles / chemistry
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Pyrroles / pharmacology
Substances
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Alkylating Agents
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Duocarmycins
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Indoles
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Oxazoles
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Pyrroles
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duocarmycin SA