Location, location, location: contrasting roles of synaptic and extrasynaptic NMDA receptors in Huntington's disease

Neuron. 2010 Jan 28;65(2):145-7. doi: 10.1016/j.neuron.2010.01.010.

Abstract

Abnormally enhanced N-methyl-D-aspartate (NMDA) receptor function is implicated in Huntington's disease (HD). In this issue of Neuron and a recent issue of Nature Medicine, an abnormal balance between the activity of NMDA receptors at synaptic (prosurvival) and extrasynaptic (proapoptotic) sites has been uncovered in a cellular and a mouse model of HD.

Publication types

  • Comment
  • Comparative Study
  • Review

MeSH terms

  • Animals
  • Humans
  • Huntington Disease / metabolism*
  • Huntington Disease / physiopathology
  • Receptors, N-Methyl-D-Aspartate / metabolism
  • Receptors, N-Methyl-D-Aspartate / physiology*
  • Synapses / metabolism
  • Synapses / physiology*
  • Synaptic Transmission / physiology*

Substances

  • Receptors, N-Methyl-D-Aspartate