Abstract
Three highly oxygenated new diterpenes, trigochinins A-C (1-3) were isolated from Trigonostemon chinensis. Their structures with the absolute configuration were determined by a spectroscopic method, X-ray crystallography, and CD analysis. This study suggested the revision of the C-6 stereochemistry of trigonothyrins A-C reported quite recently. Compound 3 showed significant inhibition against MET tyrosine kinase activity with a IC(50) value of 1.95 microM.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Crystallography, X-Ray
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Diterpenes / chemistry*
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Diterpenes / isolation & purification
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Diterpenes / pharmacology
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Euphorbiaceae / chemistry*
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Models, Molecular
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Molecular Conformation
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Plant Leaves / chemistry
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Plant Stems / chemistry
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Protein Kinase Inhibitors / chemistry*
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Protein Kinase Inhibitors / isolation & purification
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Protein Kinase Inhibitors / pharmacology
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Protein-Tyrosine Kinases / antagonists & inhibitors
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Protein-Tyrosine Kinases / metabolism
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Stereoisomerism
Substances
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Diterpenes
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Protein Kinase Inhibitors
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trigochinin A
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trigochinin B
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trigochinin C
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Protein-Tyrosine Kinases