Mesenchymal stem-cell immunosuppressive capabilities: therapeutic implications in islet transplantation

Transplantation. 2010 Feb 15;89(3):270-3. doi: 10.1097/TP.0b013e3181c6ffbe.

Abstract

Mesenchymal stem cells (MSCs) are known to be capable of suppressing immune responses and offer therapeutic potential for achieving transplantation tolerance. This review will discuss the impacts of MSCs on transplant immunity and focus on the potential role of MSCs in protecting islet grafts from both rejection and autoimmune attack.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bone Marrow Transplantation / immunology
  • Child
  • Diabetes Mellitus, Type 1 / epidemiology
  • Diabetes Mellitus, Type 1 / immunology
  • Diabetes Mellitus, Type 1 / surgery*
  • Graft Rejection / prevention & control*
  • Humans
  • Immunosuppression Therapy
  • Incidence
  • Islets of Langerhans / immunology
  • Islets of Langerhans Transplantation / immunology*
  • Mesenchymal Stem Cell Transplantation*
  • Mesenchymal Stem Cells / immunology*
  • Transplantation, Homologous / immunology