Abstract
Novel pyrazolyl-2,4-thiazolidinediones were prepared via the reaction of appropriate pyrazolecarboxaldehydes with 2,4-thiazolidinediones and substituted benzyl-2,4-thiazolidinediones. The resultant compounds were first evaluated for their anti-inflammatory and neuroprotective properties in vitro. The active compounds were further studied in vivo by using the formalin-induced paw edema and the turpentine oil-induced granuloma pouch bioassays. We identified four novel compounds that showed protective effects in vitro at non-toxic concentrations, and were also effective in the animal models of acute and sub-acute inflammation.
Copyright 2010 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Inflammatory Agents / chemical synthesis*
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Anti-Inflammatory Agents / chemistry
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Anti-Inflammatory Agents / therapeutic use
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Cell Line, Tumor
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Cyclooxygenase 1 / metabolism
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Cyclooxygenase 2 / metabolism
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Edema / chemically induced
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Edema / drug therapy
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Granuloma / chemically induced
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Granuloma / drug therapy
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HL-60 Cells
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Humans
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Neuroprotective Agents / chemical synthesis*
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Neuroprotective Agents / chemistry
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Neuroprotective Agents / therapeutic use
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Rats
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Thiazolidinediones / chemical synthesis
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Thiazolidinediones / chemistry*
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Thiazolidinediones / therapeutic use
Substances
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Anti-Inflammatory Agents
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Neuroprotective Agents
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Thiazolidinediones
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2,4-thiazolidinedione
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Cyclooxygenase 1
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Cyclooxygenase 2