Abstract
The stability of ketorolac tromethamine was investigated in acid (0.5M HCl) and alkaline conditions (0.5M NaOH), using the same procedure reported by Devarajan et al. [2]. The acid and base degradation products were identified by liquid chromatography-mass spectrometry (LC-MS).
Copyright (c) 2010 Elsevier B.V. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acids / chemistry*
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Anti-Inflammatory Agents, Non-Steroidal / analysis
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Anti-Inflammatory Agents, Non-Steroidal / chemistry*
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Chromatography, Liquid / methods
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Drug Stability
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Hot Temperature
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Hydrochloric Acid / chemistry
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Hydrolysis
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Ketorolac / analysis
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Ketorolac / chemistry*
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Mass Spectrometry / methods
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Methanol / chemistry
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Molecular Structure
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Molecular Weight
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Reference Standards
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Sodium Hydroxide / chemistry*
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Solvents / chemistry
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Time Factors
Substances
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Acids
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Anti-Inflammatory Agents, Non-Steroidal
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Solvents
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Sodium Hydroxide
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Hydrochloric Acid
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Methanol
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Ketorolac