Synthesis and biological activity of n-butylphthalide derivatives

Wei Wang; Xue-Xiang Cha; John Reiner; Yuan Gao; Hai-Ling Qiao; Jia-Xiang Shen; Jun-Biao Chang

doi:10.1016/j.ejmech.2010.01.036

Synthesis and biological activity of n-butylphthalide derivatives

Eur J Med Chem. 2010 May;45(5):1941-6. doi: 10.1016/j.ejmech.2010.01.036. Epub 2010 Jan 25.

Authors

Wei Wang¹, Xue-Xiang Cha, John Reiner, Yuan Gao, Hai-Ling Qiao, Jia-Xiang Shen, Jun-Biao Chang

Affiliation

¹ College of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, PR China.

PMID: 20133025
DOI: 10.1016/j.ejmech.2010.01.036

Abstract

A series of n-butylphthalide derivatives were designed and synthesized. The in vitro activities of these compounds were evaluated by a resting tension of isolated rat thoracic aorta ring assay. Compounds 4g and 4i were found to be more active than n-butylphthalide.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Aorta, Thoracic / drug effects*
Aorta, Thoracic / metabolism
Benzofurans / chemical synthesis*
Benzofurans / chemistry
Benzofurans / pharmacology*
Dose-Response Relationship, Drug
Drug Evaluation, Preclinical
Mice
Molecular Structure
Rats
Stereoisomerism
Vasodilator Agents / chemical synthesis*
Vasodilator Agents / chemistry
Vasodilator Agents / pharmacology*

Substances

Benzofurans
Vasodilator Agents
3-n-butylphthalide