A simple, mild, and regioselective method for the benzylation of carbohydrate derivatives promoted by silver carbonate

Satish Malik; Vaibhav A Dixit; Prasad V Bharatam; K P Ravindranathan Kartha

doi:10.1016/j.carres.2009.12.012

A simple, mild, and regioselective method for the benzylation of carbohydrate derivatives promoted by silver carbonate

Carbohydr Res. 2010 Mar 30;345(5):559-64. doi: 10.1016/j.carres.2009.12.012. Epub 2010 Jan 14.

Authors

Satish Malik¹, Vaibhav A Dixit, Prasad V Bharatam, K P Ravindranathan Kartha

Affiliation

¹ Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, Punjab, India.

PMID: 20129602
DOI: 10.1016/j.carres.2009.12.012

Abstract

A simple, mild, and regioselective method has been developed for the selective benzylation and p-methoxybenzylation of carbohydrate derivatives in high yields using Ag(2)CO(3) as the promoter. Benzylation of base-labile substrates, for which other reported methods are of little use, has been performed in high yields.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Benzene Derivatives / chemistry*
Carbohydrates / chemistry*
Carbonates / pharmacology*
Catalysis
Models, Chemical
Molecular Structure
Silver Compounds / pharmacology*
Stereoisomerism

Substances

Benzene Derivatives
Carbohydrates
Carbonates
Silver Compounds
silver carbonate