HELP for AML: methylation profiling opens new avenues

Lars Bullinger; Scott A Armstrong

doi:10.1016/j.ccr.2009.12.033

HELP for AML: methylation profiling opens new avenues

Cancer Cell. 2010 Jan 19;17(1):1-3. doi: 10.1016/j.ccr.2009.12.033.

Authors

Lars Bullinger¹, Scott A Armstrong

Affiliation

¹ Department of Internal Medicine III, University of Ulm, 89081 Ulm, Germany.

PMID: 20129241
DOI: 10.1016/j.ccr.2009.12.033

Abstract

There is growing evidence that aberrant gene expression in cancer is linked to epigenetic deregulation like promoter cytosine methylation in CpG-islands. In this issue of Cancer Cell, Figueroa et al. show that genome-wide promoter DNA methylation profiling reveals unique AML subgroups and methylation patterns that are associated with clinical outcome.

Publication types

Comment
Review

MeSH terms

DNA Methylation / genetics*
Gene Expression Profiling*
Humans
Leukemia, Myeloid, Acute / genetics*