Peritoneal adhesions in human and veterinary medicine: from pathogenesis to therapy. A review

Immunopharmacol Immunotoxicol. 2010 Sep;32(3):481-94. doi: 10.3109/08923970903524367.

Abstract

Any peritoneal inflammatory process consequent to infections or surgical injuries may induce abdominal adhesion formation. Peritoneal adhesions are connective laciniae that develop among abdomino-pelvic organs that limit physiologic visceral motion. Consequently, fertility may be impaired, and intestinal obstruction and pelvic pain may develop, mainly in subjects that had undergone gynaecological surgery. This review illustrates the pathogenic steps of adhesiogenesis and the therapeutic scenario that evolved over the years to tackle the threat of peritoneal adhesions, both in domestic animals and in women.

Publication types

  • Review

MeSH terms

  • Animals
  • Animals, Domestic / surgery
  • Anti-Bacterial Agents / therapeutic use
  • Anti-Inflammatory Agents / therapeutic use
  • Antioxidants / therapeutic use
  • Cytokines / analysis
  • Female
  • Fertility
  • Gynecologic Surgical Procedures / adverse effects
  • Humans
  • Intestinal Obstruction / drug therapy
  • Intestinal Obstruction / etiology
  • Leukocytes / immunology
  • Pelvic Pain / drug therapy
  • Pelvic Pain / etiology
  • Peritonitis / pathology*
  • Peritonitis / therapy*
  • Peritonitis / veterinary
  • Tissue Adhesions / pathology
  • Tissue Adhesions / therapy
  • Tissue Adhesions / veterinary

Substances

  • Anti-Bacterial Agents
  • Anti-Inflammatory Agents
  • Antioxidants
  • Cytokines