The relationship between maternal insulin-like growth factors 1 and 2 (IGF-1, IGF-2) and IGFBP-3 to gestational age and preterm delivery

J Perinat Med. 2010 May;38(3):255-9. doi: 10.1515/jpm.2010.019.

Abstract

Aims: To investigate the relationship between levels of insulin-like growth factors 1 and 2 (IGF-1, IGF-2), and insulin-like growth factor binding protein 3 (IGFBP-3) in antenatal maternal serum and gestational age at delivery.

Methods: Prospective cohort study of 1650 low-risk Caucasian women in a London University teaching hospital. Maternal IGF-1, IGF-2 and IGFBP-3 were measured in maternal blood at booking and analyzed with respect to gestational age at delivery.

Results: There was no significant association between maternal IGF-1 or IGF-2 and preterm birth (PTB). A significant reduction in mean IGFBP-3 levels was noted with delivery <32 completed weeks (P=0.02).

Conclusion: Maternal mean IGFBP-3 levels are significantly reduced in cases complicated by delivery <32 completed weeks.

MeSH terms

  • Adult
  • Alcohol Drinking
  • Cohort Studies
  • Female
  • Gestational Age*
  • Humans
  • Insulin-Like Growth Factor Binding Protein 3 / blood*
  • Insulin-Like Growth Factor I / analysis*
  • Insulin-Like Growth Factor II / analysis*
  • Pregnancy
  • Premature Birth / blood*
  • Prospective Studies
  • Smoking

Substances

  • Insulin-Like Growth Factor Binding Protein 3
  • Insulin-Like Growth Factor I
  • Insulin-Like Growth Factor II