Abstract
A series of 6-halo-3-hydroxyphenylcoumarins (resveratrol-coumarins hybrid derivatives) was synthesized in good yields by a Perkin reaction followed by hydrolysis. The new compounds were evaluated for their vasorelaxant activity in intact rat aorta rings pre-contracted with phenylephrine (PE), as well as for their inhibitory effects on platelet aggregation induced by thrombin in washed human platelets. These compounds concentration-dependently relaxed vascular smooth muscle and some of them showed a platelet antiaggregatory activity that was up to thirty times higher than that shown by trans-resveratrol and some other previously synthesized derivatives.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Chromonar / chemistry
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Coumarins / chemical synthesis*
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Coumarins / chemistry
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Coumarins / pharmacology*
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Female
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Humans
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In Vitro Techniques
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Inhibitory Concentration 50
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Male
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Platelet Aggregation / drug effects
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Platelet Aggregation Inhibitors / chemical synthesis*
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Platelet Aggregation Inhibitors / chemistry
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Platelet Aggregation Inhibitors / pharmacology*
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Rats
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Rats, Wistar
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Resveratrol
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Stilbenes / chemistry
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Vasodilation / drug effects
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Vasodilator Agents / chemical synthesis*
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Vasodilator Agents / chemistry
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Vasodilator Agents / pharmacology*
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Warfarin / chemistry
Substances
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Coumarins
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Platelet Aggregation Inhibitors
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Stilbenes
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Vasodilator Agents
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Warfarin
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Resveratrol
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Chromonar