Influence of amygdaloid glutamatergic receptors on sensory and emotional pain-related behavior in the neuropathic rat

Behav Brain Res. 2010 May 1;209(1):174-8. doi: 10.1016/j.bbr.2010.01.021. Epub 2010 Jan 25.

Abstract

The role of amygdaloid glutamatergic receptors (GluRs) in maintenance of the sensory versus emotional component of neuropathic pain was studied by assessing monofilament-induced limb withdrawal response (sensory pain) and aversive place-conditioning behavior (emotional pain) following amygdaloid administration of various glutamatergic compounds in nerve-injured animals. The results indicate that endogenous activation of amygdaloid group I metabotropic GluRs, mGluR(1) and mGluR(5), and the NMDA-R contributes to maintenance of sensory and emotional components of neuropathic pain. The predominant effect by amygdaloid group I mGluRs was facilitation of emotional-like pain behavior.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amygdala / drug effects
  • Amygdala / metabolism*
  • Animals
  • Emotions / drug effects
  • Emotions / physiology*
  • Excitatory Amino Acid Agonists / pharmacology
  • Excitatory Amino Acid Antagonists / pharmacology
  • Hyperalgesia / etiology
  • Male
  • Pain / etiology*
  • Pain Measurement / methods
  • Pain Threshold / drug effects
  • Pain Threshold / physiology
  • Peroneal Neuropathies / complications*
  • Peroneal Neuropathies / pathology*
  • Rats
  • Rats, Wistar
  • Receptors, Glutamate / classification
  • Receptors, Glutamate / metabolism*

Substances

  • Excitatory Amino Acid Agonists
  • Excitatory Amino Acid Antagonists
  • Receptors, Glutamate