Vinyl sulfone: a versatile function for simple bioconjugation and immobilization

Org Biomol Chem. 2010 Feb 7;8(3):667-75. doi: 10.1039/b920576d. Epub 2009 Dec 11.

Abstract

The easy functionalization of tags and solid supports with the vinyl sulfone function is a valuable tool in omic sciences that allows their coupling with the amine and thiol groups present in the proteogenic residues of proteins, in mild and green conditions compatible with their biological function.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amines / chemistry
  • Animals
  • Cattle
  • Hydrogen-Ion Concentration
  • Immobilized Proteins / chemistry*
  • Indicators and Reagents / chemistry
  • Models, Molecular
  • Protein Conformation
  • Proteins / chemistry
  • Rhodamines / chemistry
  • Silicon Dioxide / chemistry
  • Staining and Labeling
  • Sulfones / chemical synthesis
  • Sulfones / chemistry*
  • Temperature

Substances

  • Amines
  • Immobilized Proteins
  • Indicators and Reagents
  • Proteins
  • Rhodamines
  • Sulfones
  • divinyl sulfone
  • Silicon Dioxide
  • rhodamine B