Abstract
Angiogenesis is the formation of new blood vessels from pre-existing vasculature. Pathologic angiogenesis in the eye can lead to severe visual impairment. In our review, we discuss the roles of both pro-angiogenic and anti-angiogenic molecular players in corneal angiogenesis, proliferative diabetic retinopathy, exudative macular degeneration and retinopathy of prematurity, highlighting novel targets that have emerged over the past decade.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Corneal Neovascularization / genetics*
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Corneal Neovascularization / metabolism
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Eye / blood supply*
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Fibroblast Growth Factor 2 / genetics
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Fibroblast Growth Factor 2 / metabolism
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Humans
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Matrix Metalloproteinases / genetics
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Matrix Metalloproteinases / metabolism
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Polymorphism, Genetic
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Retinal Neovascularization / genetics*
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Retinal Neovascularization / metabolism
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Retinal Vessels / growth & development
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Retinal Vessels / metabolism*
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Vascular Endothelial Growth Factor A / genetics
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Vascular Endothelial Growth Factor A / metabolism
Substances
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Vascular Endothelial Growth Factor A
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Fibroblast Growth Factor 2
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Matrix Metalloproteinases