Powering reprogramming with vitamin C

Yan Shi; Yang Zhao; Hongkui Deng

doi:10.1016/j.stem.2009.12.012

Powering reprogramming with vitamin C

Cell Stem Cell. 2010 Jan 8;6(1):1-2. doi: 10.1016/j.stem.2009.12.012.

Authors

Yan Shi¹, Yang Zhao, Hongkui Deng

Affiliation

¹ Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Shenzhen Graduate School of Peking University, Shenzhen 518055, China.

PMID: 20085733
DOI: 10.1016/j.stem.2009.12.012

Abstract

In this issue of Cell Stem Cell, Esteban et al. (2009) report that vitamin C enhances the reprogramming efficiency of mouse and human fibroblasts transduced with three (Oct4/Klf4/Sox2) or four (Oct4/Klf4/Sox2/cMyc) factors. Vitamin C can alleviate cell senescence by p53 repression and may accelerate reprogramming by synergizing with epigenetic regulators.