Abstract
Clozapine induced sialorrhea is a common and troublesome adverse effect leading to poor treatment compliance. Although there are various treatment options, none has been demonstrated to be superior. In our case study, amisulpride 150 mg/d significantly reduced troublesome daytime sialorrhea along with minimal improvement in nocturnal sialorrhea.
MeSH terms
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Antipsychotic Agents / adverse effects*
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Antipsychotic Agents / therapeutic use
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Clozapine / adverse effects*
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Clozapine / therapeutic use
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Dopamine Antagonists / therapeutic use*
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Humans
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Male
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Middle Aged
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Randomized Controlled Trials as Topic
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Sialorrhea / chemically induced
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Sialorrhea / diagnosis
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Sialorrhea / drug therapy*
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Sulpiride / analogs & derivatives
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Sulpiride / therapeutic use*
Substances
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Antipsychotic Agents
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Dopamine Antagonists
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Sulpiride
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Clozapine