Amisulpride improved debilitating clozapine-induced sialorrhea

Am J Ther. 2011 May;18(3):e84-5. doi: 10.1097/MJT.0b013e3181c84bbd.

Abstract

Clozapine induced sialorrhea is a common and troublesome adverse effect leading to poor treatment compliance. Although there are various treatment options, none has been demonstrated to be superior. In our case study, amisulpride 150 mg/d significantly reduced troublesome daytime sialorrhea along with minimal improvement in nocturnal sialorrhea.

Publication types

  • Case Reports

MeSH terms

  • Antipsychotic Agents / adverse effects*
  • Antipsychotic Agents / therapeutic use
  • Clozapine / adverse effects*
  • Clozapine / therapeutic use
  • Dopamine Antagonists / therapeutic use*
  • Humans
  • Male
  • Middle Aged
  • Randomized Controlled Trials as Topic
  • Sialorrhea / chemically induced
  • Sialorrhea / diagnosis
  • Sialorrhea / drug therapy*
  • Sulpiride / analogs & derivatives
  • Sulpiride / therapeutic use*

Substances

  • Antipsychotic Agents
  • Dopamine Antagonists
  • Sulpiride
  • Clozapine