Synergistic effects between aminoethyl-chitosans and beta-lactams against methicillin-resistant Staphylococcus aureus (MRSA)

Dae-Sung Lee; Young-Mog Kim; Myung-Suk Lee; Chang-Bum Ahn; Won-Kyo Jung; Jae-Young Je

doi:10.1016/j.bmcl.2009.12.049

Synergistic effects between aminoethyl-chitosans and beta-lactams against methicillin-resistant Staphylococcus aureus (MRSA)

Bioorg Med Chem Lett. 2010 Feb 1;20(3):975-8. doi: 10.1016/j.bmcl.2009.12.049. Epub 2009 Dec 21.

Authors

Dae-Sung Lee¹, Young-Mog Kim, Myung-Suk Lee, Chang-Bum Ahn, Won-Kyo Jung, Jae-Young Je

Affiliation

¹ Department of Microbiology, Pukyong National University, Busan 608-737, Republic of Korea.

PMID: 20036533
DOI: 10.1016/j.bmcl.2009.12.049

Abstract

Two kinds of aminoethyl-chitosans (AEC), AEC90 and AEC50, which had degrees of deacetylation of 90% and 50%, respectively, were prepared and their synergistic effects in combination with beta-lactams including ampicillin, penicillin, and oxacillin against two standard methicillin-resistant Staphylococcus aureus (MRSA) strains and twelve clinical isolated MRSA strains were investigated. When AECs and beta-lactams were combined, synergistic effects were observed with fractional inhibitory concentration (FIC) indices of 0.252-0.508, and the MICs of beta-lactams in the presence of AECs were dramatically reduced.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Chitosan / administration & dosage*
Chitosan / chemistry
Drug Synergism
Drug Therapy, Combination
Methicillin-Resistant Staphylococcus aureus / drug effects*
Methicillin-Resistant Staphylococcus aureus / physiology
Microbial Sensitivity Tests / methods
beta-Lactams / administration & dosage*
beta-Lactams / chemistry

Substances

beta-Lactams
Chitosan