[Preparation and in vitro evaluation of brucine-loaded polylacticacid nanoparticles]

Zhongguo Zhong Yao Za Zhi. 2009 Sep;34(18):2322-4.
[Article in Chinese]

Abstract

Objective: To prepare and evaluate brucine-loaded polylacticacid nanoparticles (Bru-PLA-NPs).

Method: The Bru-PLA-NPs were prepared by solvent diffusion method. The physical, chemical properties and in vitro release behavior of the prepared Bru-PLA-NPs were evaluated, respectively.

Result: The mean particle size of the prepared Bru-PLA-NPs was 95 nm with polydispersity index of 0.362. The zeta potential was -15.68 mV. The mean loading and entrapment efficiency of Bru were 7% and 37%, respectively. Compared with Bru solution, an obvious sustained release behavior of Bru from Bru-PLA-NPs was observed in the in vitro release experiment.

Conclusion: The Bru-PLA-NPs prepared by solvent diffusion method exhibit small particle size, high Bru-loading efficiency, and obvious sustained release in vitro

Publication types

  • Evaluation Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Drug Carriers / chemistry*
  • Drug Delivery Systems / methods*
  • Drugs, Chinese Herbal / chemistry
  • Kinetics
  • Lactic Acid / chemistry*
  • Nanoparticles / chemistry*
  • Particle Size
  • Polyesters
  • Polymers / chemistry*
  • Strychnine / analogs & derivatives*
  • Strychnine / chemistry

Substances

  • Drug Carriers
  • Drugs, Chinese Herbal
  • Polyesters
  • Polymers
  • Lactic Acid
  • poly(lactide)
  • brucine
  • Strychnine