Norepinephrine content in the hypothalamus and medulla oblongata of ISIAH rats is regulated by several genetic loci

O E Redina; S E Smolenskaya; G S Jacobson; A L Markel

doi:10.1007/s10517-009-0663-3

Norepinephrine content in the hypothalamus and medulla oblongata of ISIAH rats is regulated by several genetic loci

Bull Exp Biol Med. 2009 Aug;148(2):223-6. doi: 10.1007/s10517-009-0663-3.

Authors

O E Redina¹, S E Smolenskaya, G S Jacobson, A L Markel

Affiliation

¹ Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia. oredina@bionet.nsc.ru

PMID: 20027334
DOI: 10.1007/s10517-009-0663-3

Abstract

Five genetic loci regulating epinephrine content in rat hypothalamus and two loci in the medulla oblongata were identified using polymorphic microsatellite DNA markers. Allele polymorphism of these loci determines the differences between norepinephrine levels in brain compartments of hypertensive ISIAH and normotensive WAG rats. The interactions between the detected epinephrine-regulating loci are additive.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Gene Expression Regulation / genetics
Hypertension / genetics*
Hypertension / physiopathology
Hypothalamus / metabolism*
Medulla Oblongata / metabolism*
Microsatellite Repeats / genetics*
Norepinephrine / genetics*
Norepinephrine / metabolism*
Polymorphism, Genetic / genetics
Rats
Rats, Wistar
Stress, Physiological / genetics*
Stress, Physiological / physiology

Substances

Norepinephrine