Radiolabelling of proteins with fluorine-18 via click chemistry

Theres Ramenda; Torsten Kniess; Ralf Bergmann; Jörg Steinbach; Frank Wuest

doi:10.1039/b916075b

Radiolabelling of proteins with fluorine-18 via click chemistry

Chem Commun (Camb). 2009 Dec 28:(48):7521-3. doi: 10.1039/b916075b. Epub 2009 Nov 4.

Authors

Theres Ramenda¹, Torsten Kniess, Ralf Bergmann, Jörg Steinbach, Frank Wuest

Affiliation

¹ Institute of Radiopharmacy, Research Center Dresden-Rossendorf, Dresden, Germany.

PMID: 20024266
DOI: 10.1039/b916075b

Abstract

The study describes for the first time the application of Cu(I)-mediated 1,3-dipolar [3+2]cycloaddition for the labelling of proteins with the short-lived positron emitter fluorine-18 as exemplified with azide-functionalized human serum albumin (HSA).

MeSH terms

Animals
Benzenesulfonamides
Copper / chemistry
Fluorine Radioisotopes / chemistry
Humans
Isotope Labeling
Mice
Mice, Nude
Positron-Emission Tomography
Serum Albumin / chemistry*
Sulfonamides / chemical synthesis
Sulfonamides / chemistry

Substances

Fluorine Radioisotopes
Serum Albumin
Sulfonamides
Copper