RNA degradation in yeast and human mitochondria

Jan Piwowarski; Andrzej Dziembowski; Aleksandra Dmochowska; Michal Minczuk; Rafal Tomecki; Kamil Gewartowski; Piotr P Stepien

doi:10.1080/15376520490257473

RNA degradation in yeast and human mitochondria

Toxicol Mech Methods. 2004;14(1-2):53-7. doi: 10.1080/15376520490257473.

Authors

Jan Piwowarski¹, Andrzej Dziembowski, Aleksandra Dmochowska, Michal Minczuk, Rafal Tomecki, Kamil Gewartowski, Piotr P Stepien

Affiliation

¹ Department of Genetics, Warsaw University and Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland.

PMID: 20021123
DOI: 10.1080/15376520490257473

Abstract

RNA turnover in yeast mitochondria is controlled by the complex called degradosome, which consists of two nuclear-encoded proteins: the SUV3 gene codes for an RNA helicase and the DSS1 gene codes for an RNase. In contrast to yeast, much less is known about RNA degradation in human mitochondria. We suggest that the key enzyme involved in this process is nuclear-encoded polynucleotide phosphorylase, hPNPase.