[PICK1 is associated with central nervous system diseases]

Zhejiang Da Xue Xue Bao Yi Xue Ban. 2009 Nov;38(6):649-54. doi: 10.3785/j.issn.1008-9292.2009.06.017.
[Article in Chinese]

Abstract

PICK1 (protein interacting with C kinase 1) contains a PDZ (PSD-95/Dlg/ZO1) domain and a BAR (Bin/amphiphysin/Rvs) domain. Via the PDZ domain, PICK1 interacts directly with more than 40 proteins. Among these interacting proteins, some are important for physiological and pathophysiological processes of central nervous system. In this review, recent findings about how PICK1 is associated with central nervous system diseases are summarize.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Carrier Proteins / chemistry*
  • Carrier Proteins / metabolism
  • Carrier Proteins / physiology*
  • Epilepsy / metabolism*
  • Humans
  • Nuclear Proteins / chemistry*
  • Nuclear Proteins / metabolism
  • Nuclear Proteins / physiology*
  • Schizophrenia / metabolism
  • Stroke / metabolism

Substances

  • Carrier Proteins
  • Nuclear Proteins
  • PICk1 protein, human