A 52-year-old male patient with advanced gastric cancer and multiple lymph node metastasis was treated by S-1/docetaxel combination chemotherapy from April, 2004. As of January 2005, after the tenth course, a scarred tumor was observed with an endoscope, and negative neoplastic cells were found on endoscopic biopsy. After the sixteenth course in July, 2005, CT scan showed that the lymph node metastasis had disappeared. The primary and metastatic lesions were regarded to have responded completely. A total of 26 courses of chemotherapies were undergone until March, 2006. We are taking a wait and see approach at this writing without treatment since then. The patient has had a recurrence-free survival for about five years since the onset. The results suggested that the S-1/docetaxel chemotherapy for metastatic gastric cancer had confirmed feasibility and sufficient efficacy while maintaining the patient's quality of life.