Abstract
A series of (Z)-5-((N-benzyl-1H-indol-3-yl)methylene)imidazolidine-2,4-dione (9a-9m) and 5-((N-benzyl-1H-indol-3-yl)methylene)pyrimidine-2,4,6(1H,3H,5H)-trione (10a-10i) derivatives that incorporate a variety of aromatic substituents in both the indole and N-benzyl moieties have been synthesized. These analogs were evaluated for their radiosensitization activity against the HT-29 cell line. Three analogs, 10a, 10b, and 10c were identified as the most potent radiosensitizing agents.
Copyright 2009 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / chemistry*
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Antineoplastic Agents / toxicity
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Barbiturates / chemical synthesis
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Barbiturates / chemistry*
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Barbiturates / toxicity
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Benzene / chemistry
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HT29 Cells
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Humans
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Indoles / chemical synthesis
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Indoles / chemistry*
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Indoles / toxicity
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Pyrimidines / chemical synthesis
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Pyrimidines / chemistry*
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Pyrimidines / toxicity
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Radiation-Sensitizing Agents / chemical synthesis
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Radiation-Sensitizing Agents / chemistry*
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Radiation-Sensitizing Agents / toxicity
Substances
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Antineoplastic Agents
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Barbiturates
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Indoles
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Pyrimidines
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Radiation-Sensitizing Agents
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indole
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Benzene