Lamivudine for the treatment of HIV

Expert Opin Drug Metab Toxicol. 2010 Jan;6(1):105-14. doi: 10.1517/17425250903490418.

Abstract

Lamivudine is a nucleoside reverse transcriptase inhibitor that is widely used for the treatment of HIV-1 infection in combination with other antiretrovirals. It is a highly effective agent that can be dosed once or twice daily due to its long intracellular half-life. It also has one of the best tolerability and long-term safety profiles among all antiretroviral agents and continues to be preferred as part of initial or subsequent combination therapy in HIV-infected patients.

Publication types

  • Review

MeSH terms

  • Animals
  • Anti-HIV Agents / adverse effects
  • Anti-HIV Agents / metabolism
  • Anti-HIV Agents / pharmacokinetics
  • Anti-HIV Agents / pharmacology
  • Anti-HIV Agents / therapeutic use*
  • Clinical Trials as Topic
  • Drug Utilization
  • HIV Infections / drug therapy*
  • HIV Infections / epidemiology
  • HIV Infections / virology
  • HIV-1
  • Humans
  • Lamivudine / adverse effects
  • Lamivudine / metabolism
  • Lamivudine / pharmacokinetics
  • Lamivudine / pharmacology
  • Lamivudine / therapeutic use*
  • Legislation, Drug
  • Reverse Transcriptase Inhibitors / adverse effects
  • Reverse Transcriptase Inhibitors / metabolism
  • Reverse Transcriptase Inhibitors / pharmacokinetics
  • Reverse Transcriptase Inhibitors / therapeutic use*

Substances

  • Anti-HIV Agents
  • Reverse Transcriptase Inhibitors
  • Lamivudine