Abstract
Cerebral toxoplasmosis is a major cause of morbidity and mortality among HIV-infected patients, particularly from developing countries. This article summarizes current literature on cerebral toxoplasmosis. It focuses on: Toxoplasma gondii genetic diversity and its possible relationship with disease presentation; host responses to the parasite antigens; host immunosupression in HIV and cerebral toxoplasmosis as well as different diagnostic methods; clinical and radiological features; treatment; and the direction that studies on cerebral toxoplasmosis will likely take in the future.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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AIDS-Related Opportunistic Infections / diagnosis
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AIDS-Related Opportunistic Infections / drug therapy
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AIDS-Related Opportunistic Infections / parasitology*
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AIDS-Related Opportunistic Infections / pathology
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Animals
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Biomedical Research / trends
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Genetic Variation
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HIV Infections / complications*
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HIV Infections / immunology
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Humans
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Toxoplasma / genetics
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Toxoplasma / pathogenicity
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Toxoplasmosis, Cerebral / diagnosis
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Toxoplasmosis, Cerebral / drug therapy
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Toxoplasmosis, Cerebral / parasitology*
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Toxoplasmosis, Cerebral / pathology