Abstract
Sinemet CR, a controlled release carbidopa/levodopa preparation, was compared to conventional carbidopa/levodopa in a double blind, placebo-controlled trial. Comparable clinical benefits and adverse effects were noted with the two medications. However significantly less frequent dosing was necessary with Sinemet CR.
Publication types
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Clinical Trial
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Comparative Study
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Randomized Controlled Trial
MeSH terms
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Aged
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Antiparkinson Agents / administration & dosage
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Antiparkinson Agents / therapeutic use*
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Carbidopa / administration & dosage
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Carbidopa / therapeutic use*
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Double-Blind Method
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Drug Administration Schedule
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Drug Combinations
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Female
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Humans
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Levodopa / administration & dosage
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Levodopa / therapeutic use*
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Male
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Middle Aged
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Parkinson Disease / drug therapy*
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Placebos
Substances
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Antiparkinson Agents
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Drug Combinations
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Placebos
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carbidopa, levodopa drug combination
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Levodopa
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Carbidopa