Secondary metabolites from the mangrove endophytic fungus Penicillium sp. (SBE-8)

Nat Prod Commun. 2009 Nov;4(11):1481-3.

Abstract

A new metabolite, 7-hydroxyjanthinone (1), was isolated from the mangrove endophytic fungus Penicillium sp. (SBE-8), together with two known compounds, janthinone (2) and citrinin (3). The structures of these compounds were identified by spectroscopic methods. Compounds 1 and 2 showed no cytotoxicity against KB and KBv cell lines when tested by the MTT method, but compound 3 was weakly active.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibiotics, Antineoplastic / biosynthesis*
  • Antibiotics, Antineoplastic / chemistry*
  • Coloring Agents
  • Fermentation
  • Heterocyclic Compounds, 3-Ring / chemistry*
  • Heterocyclic Compounds, 3-Ring / metabolism*
  • Humans
  • KB Cells
  • Magnetic Resonance Spectroscopy
  • Penicillium / chemistry*
  • Penicillium / metabolism*
  • Rhizophoraceae / microbiology*
  • Spectrometry, Mass, Electrospray Ionization
  • Spectrophotometry, Infrared
  • Spectrophotometry, Ultraviolet
  • Tetrazolium Salts
  • Thiazoles

Substances

  • 7-hydroxyjanthinone
  • Antibiotics, Antineoplastic
  • Coloring Agents
  • Heterocyclic Compounds, 3-Ring
  • Tetrazolium Salts
  • Thiazoles
  • thiazolyl blue