Novel neofusapyrones isolated from Verticillium dahliae as potent antifungal substances

Bioorg Med Chem Lett. 2010 Jan 15;20(2):709-12. doi: 10.1016/j.bmcl.2009.11.063. Epub 2009 Dec 3.

Abstract

Novel fusapyrone analogs, deoxyneofusapyrone and 7-desmethyldeoxyneofusapyrone were isolated from a pathogenic fungus, Verticillium dahliae, which causes Verticillium wilt disease in Helianthus annuus. Spectral analyses revealed that these are 2-pyrone type analogs of deoxyfusapyrone and its 7-desmethyl derivative, respectively. Biological assay disclosed that 10microg of deoxyneofusapyrone inhibited the growth of MRSA clinical isolate 87-7927.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antifungal Agents / chemistry*
  • Antifungal Agents / isolation & purification
  • Antifungal Agents / pharmacology
  • Glucosides / chemistry*
  • Glucosides / isolation & purification
  • Glucosides / pharmacology
  • Methicillin-Resistant Staphylococcus aureus / drug effects
  • Models, Chemical
  • Pyrones / chemistry*
  • Pyrones / isolation & purification
  • Pyrones / pharmacology
  • Verticillium / chemistry*

Substances

  • 7-desmethyldeoxyneofusapyrone
  • Antifungal Agents
  • Glucosides
  • Pyrones
  • deoxyneofusapyrone
  • fusapyrone