Abstract
Novel fusapyrone analogs, deoxyneofusapyrone and 7-desmethyldeoxyneofusapyrone were isolated from a pathogenic fungus, Verticillium dahliae, which causes Verticillium wilt disease in Helianthus annuus. Spectral analyses revealed that these are 2-pyrone type analogs of deoxyfusapyrone and its 7-desmethyl derivative, respectively. Biological assay disclosed that 10microg of deoxyneofusapyrone inhibited the growth of MRSA clinical isolate 87-7927.
Copyright 2009 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antifungal Agents / chemistry*
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Antifungal Agents / isolation & purification
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Antifungal Agents / pharmacology
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Glucosides / chemistry*
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Glucosides / isolation & purification
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Glucosides / pharmacology
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Methicillin-Resistant Staphylococcus aureus / drug effects
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Models, Chemical
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Pyrones / chemistry*
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Pyrones / isolation & purification
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Pyrones / pharmacology
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Verticillium / chemistry*
Substances
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7-desmethyldeoxyneofusapyrone
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Antifungal Agents
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Glucosides
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Pyrones
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deoxyneofusapyrone
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fusapyrone