Hypoxia affected SDF-1alpha-CXCR4 interaction between bone marrow stem cells and osteoblasts via osteoclast modulation

Acta Haematol. 2010;123(1):43-7. doi: 10.1159/000262750. Epub 2009 Dec 2.
No abstract available

MeSH terms

  • 3T3 Cells
  • Animals
  • Base Sequence
  • Cathepsin K / genetics
  • Cell Communication
  • Cell Differentiation / drug effects
  • Cell Hypoxia / drug effects
  • Cell Hypoxia / genetics
  • Cell Hypoxia / physiology*
  • Cell Line
  • Chemokine CXCL12 / metabolism*
  • Cobalt / toxicity
  • DNA Primers / genetics
  • Female
  • Hematopoietic Stem Cell Mobilization / methods
  • Hematopoietic Stem Cells / metabolism*
  • Hypoxia-Inducible Factor 1, alpha Subunit / genetics
  • In Vitro Techniques
  • Matrix Metalloproteinase 9 / genetics
  • Mice
  • Mice, Inbred C57BL
  • Osteoblasts / metabolism*
  • Osteoclasts / cytology
  • Osteoclasts / drug effects
  • Osteoclasts / metabolism*
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism
  • Receptors, CXCR4 / metabolism*
  • Up-Regulation

Substances

  • CXCR4 protein, mouse
  • Chemokine CXCL12
  • DNA Primers
  • Hif1a protein, mouse
  • Hypoxia-Inducible Factor 1, alpha Subunit
  • RNA, Messenger
  • Receptors, CXCR4
  • Cobalt
  • Cathepsin K
  • Ctsk protein, mouse
  • Matrix Metalloproteinase 9
  • Mmp9 protein, mouse
  • cobaltous chloride