Two new isopimarane diterpenes from the feces of Trogopterus xanthipes

Nian-Yun Yang; Wei-Wei Tao; Min Zhu; Jin-Ao Duan; Jian-Guo Jiang

doi:10.1016/j.fitote.2009.11.006

Two new isopimarane diterpenes from the feces of Trogopterus xanthipes

Fitoterapia. 2010 Jul;81(5):381-4. doi: 10.1016/j.fitote.2009.11.006. Epub 2009 Nov 30.

Authors

Nian-Yun Yang¹, Wei-Wei Tao, Min Zhu, Jin-Ao Duan, Jian-Guo Jiang

Affiliation

¹ Jiangsu Key Laboratory for TCM Formulae Research, Nanjing University of Traditional Chinese Medicine, Nanjing, China.

PMID: 19954761
DOI: 10.1016/j.fitote.2009.11.006

Abstract

Chemical investigation of Trogopterus Feces has led to the isolation of two new isopimarane diterpenes, wulingzhic acid A (1) and wulingzhic acid B (2). Their structures were elucidated by chemical and extensive spectral analysis. Compounds 1 and 2 exhibited weak activity of antithrombin and moderate activity of antiplatelet aggregation in vitro.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Anticoagulants / chemistry
Anticoagulants / isolation & purification*
Anticoagulants / pharmacology
Antithrombins / chemistry
Antithrombins / isolation & purification*
Antithrombins / pharmacology
Diterpenes / chemistry
Diterpenes / isolation & purification*
Diterpenes / pharmacology
Feces / chemistry*
Medicine, Chinese Traditional
Platelet Aggregation / drug effects*
Sciuridae*

Substances

Anticoagulants
Antithrombins
Diterpenes
wulingzhic acid A
wulingzhic acid B