Steric decompression of picket-strapped porphyrins for the synthesis of side-differentiated chelates

S Balieu; I Hijazi; N Motreff; F Lachaud; P Even-Hernandez; B Boitrel

doi:10.1021/ol902513c

Steric decompression of picket-strapped porphyrins for the synthesis of side-differentiated chelates

Org Lett. 2010 Jan 1;12(1):8-11. doi: 10.1021/ol902513c.

Authors

S Balieu¹, I Hijazi, N Motreff, F Lachaud, P Even-Hernandez, B Boitrel

Affiliation

¹ Université de Rennes1-Sciences Chimiques de Rennes, UMR CNRS 6226 (I.C.M.V.), 35042 Rennes, France.

PMID: 19954167
DOI: 10.1021/ol902513c

Abstract

A general method to synthesize various alphabeta alphabeta bis-strapped porphyrins, with a different functionalization on each side of the macrocycle, is described. The resulting new chelates may find applications as analogues of heme protein active sites, bifunctional chelates, or specific bis-chelating molecules with potential medical utility.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Binding Sites
Chelating Agents / chemical synthesis*
Chelating Agents / chemistry
Hemeproteins / drug effects
Metalloporphyrins / chemical synthesis*
Metalloporphyrins / chemistry
Models, Molecular
Molecular Structure
Stereoisomerism

Substances

Chelating Agents
Hemeproteins
Metalloporphyrins