Design and synthesis of highly potent and plasma-stable dimeric inhibitors of the PSD-95-NMDA receptor interaction

Angew Chem Int Ed Engl. 2009;48(51):9685-9. doi: 10.1002/anie.200904741.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Binding Sites
  • Computer Simulation
  • Dimerization
  • Drug Design
  • Humans
  • Ligands
  • Nerve Tissue Proteins / antagonists & inhibitors
  • Nerve Tissue Proteins / metabolism*
  • Peptides / chemical synthesis*
  • Peptides / chemistry
  • Plasma / metabolism
  • Protein Structure, Tertiary
  • Receptors, N-Methyl-D-Aspartate / antagonists & inhibitors
  • Receptors, N-Methyl-D-Aspartate / metabolism*

Substances

  • Ligands
  • Nerve Tissue Proteins
  • Peptides
  • Receptors, N-Methyl-D-Aspartate
  • postsynaptic density proteins