Association of FcRn Heavy Chain Encoding Gene (FCGRT) Polymorphisms with IgG Content in Bovine Colostrum

Anim Biotechnol. 2009;20(4):242-6. doi: 10.1080/10495390903196448.

Abstract

In this study, we evaluated haplotypes of the bovine FCGRT (encoding the FcRn heavy chain) and their relationship to the IgG concentration in bovine colostrum. Four single nucleotide polymorphism (SNP), classified into five haplotypes, were identified in a total of 49 Holstein-Frisians cows. Haplotype 5 was found to be significantly associated with a high IgG level ([OR] = 9.90, 95%CI = 1.11-88.34, p = 0.016) and haplotype 2 exhibited a similar trend ([OR] = 2.89, 95%CI = 1.17-7.11, p = 0.019).

MeSH terms

  • Alleles
  • Animals
  • Cattle / genetics*
  • Cattle / immunology
  • Colostrum / chemistry*
  • Colostrum / immunology
  • Haplotypes
  • Histocompatibility Antigens Class I / genetics*
  • Histocompatibility Antigens Class I / immunology
  • Immunoglobulin G / analysis*
  • Immunoglobulin G / immunology
  • Polymorphism, Single Nucleotide*
  • Receptors, Fc / genetics*
  • Receptors, Fc / immunology

Substances

  • Histocompatibility Antigens Class I
  • Immunoglobulin G
  • Receptors, Fc
  • Fc receptor, neonatal