Examination of candidate genes for hypoadrenocorticism in Nova Scotia Duck Tolling Retrievers

Angela M Hughes; Danika L Bannasch; Kristin Kellett; Anita M Oberbauer

doi:10.1016/j.tvjl.2009.10.012

Examination of candidate genes for hypoadrenocorticism in Nova Scotia Duck Tolling Retrievers

Vet J. 2011 Feb;187(2):212-6. doi: 10.1016/j.tvjl.2009.10.012.

Authors

Angela M Hughes¹, Danika L Bannasch, Kristin Kellett, Anita M Oberbauer

Affiliation

¹ Department of Animal Science, University of California, Davis, CA 95616, USA.

PMID: 19931476
DOI: 10.1016/j.tvjl.2009.10.012

Abstract

Inherited hypoadrenocorticism occurs in some dog breeds including the Nova Scotia Duck Tolling Retriever (NSDTR) and is thought to be due to an immune attack on the adrenal glands. The genetic cause of this disorder in dogs has not been identified; however, many genes have been associated with hypoadrenocorticism and other immune-mediated conditions in humans including AIRE, BAFF, Casp10, CD28, CTLA-4, FASL, PTPN22, and TNFRSF6B. Microsatellite marker loci were analysed for linkage with the disease phenotype in a pedigree of NSDTRs and excluded all genes examined, the exception being CTLA-4, which was neither excluded nor shown to be associated by this analysis. Thus, genes associated with hypoadrenocorticism in humans were not linked with the condition in the dog. Further examination is necessary to identify the genetic cause of inherited hypoadrenocorticism in dogs and this may reveal a novel gene not yet implicated with immune-mediated disease.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Addison Disease / genetics
Addison Disease / veterinary*
Animals
Dog Diseases / genetics*
Dogs
Female
Genetic Association Studies / veterinary*
Genetic Predisposition to Disease
Male
Nova Scotia
Pedigree
Species Specificity